Dermatology, Internal Medicine, Allergology, Cosmetic Dermatology, Cosmetic Internal Medicine

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Dermatology, Internal Medicine, Allergology, Cosmetic Dermatology, Cosmetic Internal Medicine

Wrinkles

SUNEKOS Injection

A blend of six amino acids and non-cross-linked hyaluronic acid in an optimal ratio acts on the extracellular matrix (ECM) to enhance collagen and elastin synthesis, restoring the skin’s firmness and radiance.

Recommended for those who:

  • Have developing lines between the eyebrows, on the forehead, or at the outer corners of the eyes
  • Concerned about fine lines on the face
  • Loss of skin elasticity
  • Desire for better skin texture, firmness, and radiance
  • Concerned about wrinkles on the neck, décolletage, or back of the hands
  • Want to improve forehead or between-the-brow wrinkles without using Botox

What is SUNEKOS?

SUNEKOS is an injectable treatment developed in Italy that combines non-cross-linked hyaluronic acid with amino acids.

The ECM (extracellular matrix), represented by collagen, elastin, and hyaluronic acid, is the component that forms the essential foundation for skin firmness, elasticity, and moisture.
As the ECM diminishes with age, not only are firmness and elasticity lost, but skin cell differentiation and homeostasis are also disrupted, leading to skin issues. Therefore, maintaining a proper ECM environment is crucial for creating healthy, beautiful skin.

SUNEKOS focuses on the ECM, containing six types of amino acids specifically formulated in an internationally patented optimal ratio to stimulate the production of elastin and collagen.
Because it is a highly simple formulation of amino acids and non-cross-linked hyaluronic acid, side effects are minimal, and a natural rejuvenating effect can be expected.

The ideal treatment course consists of four sessions at intervals of one to two weeks, followed by regular maintenance treatments.

Case photos
SUNEKOS Formulations

  • Improvement of Firmness: Replenishes collagen and elastin lost due to aging.
  • Excellent Restorative Action: Improves the skin’s own regenerative power and enhances self-recovery capabilities.
  • Restoration of Sebum and Moisture Balance: Restores the balance between oil and water to improve skin texture.
  • Superior Safety: With a simple composition of non-cross-linked hyaluronic acid and amino acids, adverse reactions are extremely rare.
  • Improvement at the Cellular Level: Acts on the ECM to promote rejuvenation at the cellular level.

Treatment details

Treatment Interval One course consists of 4 sessions, once every 1–2 weeks
Treatment Time 20–30 minutes
Anaesthesia Topical anaesthesia; block injection upon request
Downtime Redness or swelling may occur immediately after the procedure, but usually subsides within a few hours.
Internal bleeding (bruising) may occur. While individual results vary, it typically settles within 1–3 weeks.
Makeup Possible immediately after, avoiding the needle marks
Follow-up visits None in particular
Face washing / shower / bathing No restrictions
Medication None in particular
Recommended combination treatments ・High-concentration Salmon Injection (PDRN)
・Hyaluronic Acid
・Botox
・Skin-tightening Thread Treatments
Post-treatment notes None in particular
Contraindications *Those who are pregnant or breastfeeding
*Those with an allergy to hyaluronic acid

SonoQueen (HIFU)

A ‘non-surgical skin tightening treatment’ that uses the power of ultrasound to effectively target the SMAS layer (superficial musculoaponeurotic system) and dermal layer, the root causes of sagging!

Recommended for those who:

  • Improve sagging without downtime
  • Lack of skin firmness
  • Concerned about wrinkles
  • Do not wish to undergo treatments involving scalpels, needles, or implants

What is SONOQUEEN

SONOQUEEN is the latest skin tightening device utilizing HIFU (High-Intensity Focused Ultrasound). HIFU energy is also utilized in cancer treatment.
Lift-up machines utilizing HIFU energy are characterized by their ability to avoid damaging the skin surface.
Among these devices, SONOQUEEN employs original cartridges that accurately deliver heat of 60–70°C from the dermal layer to the SMAS layer (superficial musculoaponeurotic system), which causes sagging. While an immediate contraction effect occurs at the treated area, collagen production continues over 1–3 months, resulting in both internal lift-up and skin tightening effects.
At our clinic, trained practitioners carefully perform treatments using three types of cartridges—4.5 mm, 3.0 mm, and 2.0 mm—selected according to the treatment area and target depth.

Three types of cartridges target each layer!

4.5 mm: Targets the SMAS layer (superficial musculoaponeurotic system)!

Thermal energy is delivered to the SMAS layer, a fascia that supports the skin beneath the dermal layer. Damaged proteins contract tightly, tightening the laxity in both the dermal and SMAS layers, resulting in a lift-up effect.

3.0 mm: Activates collagen in the dermal layer!

Thermal energy damages fibers within the dermal layer, but the wound-healing process that repairs the damaged fibers activates collagen regeneration, enhancing firmness and elasticity. A further tightening effect is felt over the course of one month.

2.0 mm: Eye Shadow HIFU!

HIFU thermal energy is delivered to delicate areas with thin skin and curves, such as around the eyes, under the eyebrows, and the forehead, which were difficult to treat with conventional technology.
A dedicated mini cartridge for SONOQUEEN targets superficial wrinkles.

Features of SONOQUEEN

  • Heat accurately reaches the targeted layer with minimal pain
  • The 2.0 mm mini cartridge enables detailed treatment around the eyes
  • No downtime, with naturally noticeable results
  • 40–50 minute treatment with effects lasting approximately 6 months to 1 year

Eye Shadow HIFU

At our clinic, we use a dedicated Eye Shadow HIFU cartridge with a 5.0 mm irradiation opening to perform detailed treatment around the eyes and forehead. It is possible to irradiate up to the very edge of the bone for wrinkles and sagging above and below the eyes and eyebrows, as well as on the forehead. SONOQUEEN’s unique cartridge, which delivers thermal energy to a depth of 2.0 mm, enables accurate irradiation even in areas with thin skin or near nerves. Patients who wish to avoid injection or filler treatments around the eyes can receive this treatment with confidence.

Treatment details

No medication required

Treatment Interval Once every 6 months to 1 year
Treatment Time 40–50 minutes
Anesthesia None
Downtime Almost none. You may apply makeup and leave immediately after treatment.
Makeup After treatment
Follow-up visits None in particular
Face Washing, Showering, Bathing No restrictions
Recommended combination treatments Thread Lift, Hyaluronic Acid, Botox, Genesis, Limelight
Contraindications Patients with skin diseases, keloids, or severe heart conditions
Post-Treatment Precautions Redness will subside within approximately 30 minutes. Some patients may experience mild swelling, which will resolve within a few days.
There are no restrictions on daily activities such as drinking alcohol, exercising, or bathing.

High-Concentration Salmon Injection

Revitalize your natural skin beauty. Experience hydration, firmness, and clarity.
PDRN injections extracted from salmon regenerate damaged or aging skin.
LIZNE is characterized by higher purity compared to conventional PDRN products, making post-treatment redness less likely, and features reduced pain due to its adjusted pH level.

Recommended for those who:

  • Want smoother texture, firmness, and radiance
  • Are concerned about fine lines on the face
  • Are concerned about wrinkles on the neck, décolletage, and backs of the hands
  • Those concerned about acne scars or surgical scars
  • Those who wish to improve deep-set wrinkles that do not respond to Botox

What is LIZNE?

LIZNE is an injectable treatment primarily composed of PDRN (Polydeoxyribonucleotide) extracted from trout of the Salmonidae family. PDRN is approved as a pharmaceutical product in Europe and is widely used in medical settings for wound healing (skin grafts, burns, scars) and in orthopedics for cartilage and ligament injuries. Unlike treatments like hyaluronic acid fillers that physically add volume to make wrinkles less noticeable, LIZNE works directly on the damaged skin itself. It is a new concept in skin cell regeneration therapy that restores healthy, firm, and elastic skin from within by increasing dermal fibroblasts and promoting the regeneration and increase of collagen and elastin.
It is suitable for deep-set wrinkles, scars, fine lines around the eyes, and overall skin texture improvement. While salmon-derived PDRN is highly biocompatible with the human body and has few side effects, it cannot be administered to those with fish or fish egg allergies.

In particular, LIZNE is characterized by low impurity levels, making post-treatment redness less likely, and features less pain than conventional products because the pH of the solution has been adjusted.

Salmon Injection and Collagen Activation
Treatment Areas for Salmon Injection

Activation of Fibroblasts: Activates fibroblasts in the dermis to produce collagen, elastin, and hyaluronic acid, promoting the regeneration of damaged skin.

Angiogenesis: Creates and regenerates capillaries that decrease with age, improving blood flow in the skin.

Anti-inflammatory Effect: Suppresses skin inflammation and improves skin issues caused by inflammation.


Treatment details

Treatment Interval Once every 2 to 3 weeks. 4 to 5 sessions in total.
Treatment Time 15 minutes (per treatment area)
Anaesthesia Topical anaesthesia; block injection upon request
Downtime Redness, swelling, or unevenness may occur immediately after the procedure, but these usually subside within a few hours.
Internal bleeding (bruising) may occur. While it varies by individual, it typically subsides in about 1 to 3 weeks.
Makeup Possible immediately after
Follow-up visits None in particular
Face washing / shower / bathing No restrictions
Medication None in particular
Recommended combination treatments ・Genesis ・Limelight ・Tightening Thread Treatments
Post-Treatment Precautions Please refrain from activities such as intense massaging of the injection site for about half a month.
Contraindications Those with fish or fish egg allergies. *Please consult with us in advance if you are pregnant or breastfeeding.
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